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The granulomatous reactions represent immune reactions to an inciting antigen and may be associated with systemic disease. 1 annular elastolytic giant cell granuloma (aegcg) is a rare variant of the granulomatous skin diseases with destruction of elastic fibers after phagocytosis by histiocytes and multinucleated giant cells in the dermis. Typically, aegcg is clinically characterized by solitary or grouped papules forming annular plaques with elevated borders and central atrophy.
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Annular elastolytic giant-cell granuloma (also known as giant cell elastophagocytosis, meischer's granuloma, miescher's granuloma of the face) is a cutaneous condition characterized histologically by a dermal infiltrate of macrophages.
Annular elastolytic giant cell granuloma (aegcg) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells.
(case report of an elderly man with expanding lesions of actinic granuloma (common variant of annular elastolytic giant cell granuloma) on the forehead and nose. Treatment with acitretin 25 mg by mouth daily was associated with remarkable improvement.
Regarding medical treatment hydroxychloroquine, clofazimine, dapsone, intralesional, and systemic steroid has been used in annular elastolytic giant cell granuloma (aegg) of skin. Surgical excision is considered to be the treatment of choice.
A nnular elastolytic giant cell granuloma (aegcg) is an inflammatory eruption characterized clinically by erythematous papules and annular plaques on sun-exposed skin and histologically by granulomatous inflammation accompanied by loss of elastic tissue and elastophagocytosis. We report the case of a man with aegcg who subsequently developed acute myelogenous leukemia (aml) and in whom the aegcg behaved in a fashion parallel with his leukemia.
Annular elastolytic giant cell granuloma (aegcg) is a rare granulomatous disorder characterized by giant cells in the dermis phagocytosing damaged elastin fragments. Objective: we report a case of a 71-year-old man presenting with erythematous plaques in predominantly sun-exposed areas.
Annular elastolytic giant cell granuloma is a histiocytic / granulomatous dermal infiltrate that results in phagocytosis and destruction of elastic fibres. Atypical facial necrobiosis lipoidica is probably best considered a form of this disorder and because of this there is confusion in nomenclature.
Annular elastolytic giant cell granuloma initially described by o'brien in 1975 is a disorder of uncertain etiopathogenesis presenting with annular erythematous plaques predominantly on the sun-exposed areas. Hisptopathologically, it is characterized by elastin degenration, multinucleate giant cells, and elastophagocytosis.
Annular elastolytic giant cell granuloma is a rare granulomatous skin disease, clinically similar to granuloma annular, but with different histopatologi- cal aspects. In this article, we report a male patient case, with lesions on his arms and nape, which diagnosis was obtained trough anatopatological.
Elastophagocytosis is the phagocytosis of elastic fibers that can microscopically be seen in the cytoplasm of histiocytes, multinucleated giant cells, or both. Generally believed to be a characteristic feature of certain granulomatous disorders such as annular elastolytic giant cell granuloma or elastolytic disorders such as mid-dermal elastolysis, this feature has also been described in other.
Annular elastolytic giant cell granuloma (aegcg) is rare granulomatous dermatoses of uncertain pathogenesis. Clinically characterized by annular plaques with well defined erythematous borders with a normal or atrophic center in a polycyclical pattern which usually presents itself in photoexposed areas of the skin.
Annular elastolytic giant cell granuloma is a granulomatous process that presents as slowly growing annular papules and plaques on sun-exposed skin. It was first described in patients in the fourth and fifth decades of life. These lesions are primarily distributed on the head and neck. A review of the literature shows a preponderance of cases in adults.
Annular elastolytic giant cell granuloma causes an irreversible disappearance of the elastic fibres. Systemic elastolytic granulomatosis with cutaneous, ocular, lymph nodal, and intestinal involvement.
Annular elastolytic giant cell granuloma (aegcg) is a rare form of granulomatous dermatoses, characterized histologically by phagocytosis of elastic fibers by multinucleated giant cells.
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Het annular elastolytic giant cell granuloma (synoniem: actinic granuloma, granuloma actinica) is een onduidelijke entiteit, mogelijk een variant van granuloma.
Annular elastolytic giant cell granuloma (aegcg) is a rare granulomatous dermatosis of controversial origin characterized by loss of elastic fibers and elastophagocytosis by multinucleated giant cells lesions of aegcg are usually located on sun-exposed areas we present two patients with aegcg both involving sun-exposed and covered areas.
Annular elastolytic giant cell granuloma (aegcg) is an inflammatory eruption characterized clinically by erythematous papules and annular plaques on sun-exposed skin and histologically by granulomatous inflammation accompanied by loss of elastic tissue and elastophagocytosis.
Request pdf elastolytic actinic giant cell granuloma actinic granuloma and annular elastolytic giant cell granuloma are different terms used to define skin lesions characterized by elastolysis.
Generalized annular elastolytic giant cell granuloma successfully treated with the long-term use of minocycline hydrochloride.
Elastolytic giant cell granuloma (egcg), also known as actinic granuloma, is an uncommon granulomatous dermatosis usually characterised by asymptomatic annular plaques on sun-exposed skin. Its aetiology is not fully elucidated, but actinic damage has been considered the main causal factor.
Annular elastolytic giant cell granuloma successfully treated with minocycline hydrochloride ai nanbu, kazumitsu sugiura*, michihiro kono, yoshinao muro and masashi akiyama department of dermatology, nagoya university graduate school of medicine, 65 tsurumai-cho, showa-ku nagoya 466-8550, japan.
24 dec 2001 annular elastolytic giant cell granuloma is a rare granulomatous skin disease characterized by phagocytosis of elastic fibres by multinucleated.
A 70‐year‐old man with a 2‐year history of annular elastolytic giant cell granuloma associated with diabetes mellitus was reported. Histologic examination revealed phagocytosis of elastic fibers by histiocytic cells. Immunoperoxidase staining for lysozyme disclosed positive reactivity within the cytoplasm of these histiocytic.
27 jun 2020 annular elastolytic giant cell granuloma (aegcg) is a rare granulomatous skin disease of undetermined cause, characterized by annular plaques.
Giant cell annular elastolytic granuloma is a rare granulomatous disease characterized by the presence of multinucleated giant cells phagocytizing anomalous elastic fibers. Clinically, it manifests as an annular plaque with central hypopigmentation, predominantly in photo-exposed areas.
These findings are compatible with annular elastolytic giant cell granuloma. Treatment with intralesional triamcinolone acetonide (40 mg/5 ml) every 4 weeks resulted in a gradual involution of the annular lesions within 3 months. The papular lesions on the forearms and on the upper portion of the back spontaneously regressed.
A number of diseases have been reported to coexist with aegcg, such as alcoholic liver disease, diabetes, and temporal arteritis. 8,9 annular elastolytic giant cell granuloma has a chronic course, and spontaneous resolution may take place after many years. It is usually refractory to treatment with topical or intralesional corticosteroids but has been reportedly responsive to treatment with antimalarial agents, cyclosporine, isotretinoin, and pentoxyfylline.
Annular elastolytic giant cell granuloma (aegcg) is a rare, often self-limiting chronic inflammatory disorder mostly occurring in the sun-exposed areas such as the dorsum of hands, extensor surfaces of arms, face, anterior neck, and upper chest. The pathognomonic histological findings include the presence of numerous granulomas associated with loss of elastic fibers that appear to be ingested by multi-nucleated giant cells.
Annular elastolytic giant cell granuloma: histiocytes and foreign body giant cells engulfing elastotic fibers; may be a related entity necrobiosis lipodica: ill defined areas of disintegrating dermal collagen, surrounded by palisading lymphocytes and histiocytes, with thick walled vessels, usually in reticular dermis.
Annular elastolytic giant cell granuloma, is a rare granulomatous disease characterized by annular erythematous plaques with central atrophy, which is generally observed in the sun-exposed areas of the skin. Actinic injury is thought to be involved in pathogenesis, yet its exact reason has not been elucidated.
Hair repigmentation can be a clinical clue to a subjacent inflammatory disease. Hair depigmentation associated with aging may be a reversible condition under.
A clinicopathologic study of five cases and a review of similar entities. Five patients with annular lesions of the face, scalp, and other exposed surfaces were studied using the radial triple zone biopsy technic.
Annular elastolytic giant cell granuloma is a rare granulomatous skin disease characterized by phagocytosis of elastic fibres by multinucleated giant cells.
Annular elastolytic giant cell granuloma (aegcg) previously known as annular necrobiosis lipoidica (nl) and actinic granuloma (ag) has recently been proved to be a distinct entity. [1] [2] it is a granulomatous process that presents as slowly growing papules and plaques over sun-exposed skin.
Annular elastolytic giant cell granuloma, also known as actinic granuloma, is a rare skin condition with a chronic course that is often resistant to treatment. Literature is sparse, and only a handful of case reports are available to guide treatment decisions. Typical first line treatment options include topical and intralesional steroids, topical pimecrolimus, and cryotherapy.
Treatment of annular elastolytic giant cell granuloma with topical tretinoin pannular elastolytic giant cell granuloma, also known as actinic granuloma, is a rare skin condition with a chronic course that is often resistant to treatment. Literature is sparse, and only a handful of case reports are available to guide treatment decisions.
Annular elastolytic giant cell granuloma initially described by o'brien in 1975 is a disorder of uncertain etiopathogenesis presenting with annular erythematous.
Background: annular elastolytic giant-cell granuloma (aegcg) is a rare form of granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins and is usually located on the facial and neck areas. It is characterized histologically by loss of elastic fibre and elastophagocytosis.
Actinic granuloma, o'brien granuloma, actinic elastosis, annular elastolytic giant cell granuloma, giant cell elastophagocytosis, meischer granuloma of the face.
Here are links to possibly useful sources of information about annular elastolytic giant-cell granuloma. Pubmed provides review articles from the past five years (limit to free review articles ) the trip database provides clinical publications about evidence-based medicine.
Annular elastolytic giant cell granuloma (aegcg) is an uncommon condition belonging to the family of elastolytic granuloma, which also includes actinic granuloma, atypical necrobiosis lipoidica of the face and scalp, and miescher's granuloma. 1 classification of aegcg as a distinct entity has been controversial. Although some consider it synonymous with actinic granuloma, a term often used.
No diabetes or other systemic diseases were found during clinical survey. The patient then received topical clobetasol proprionate foam for 1 month without obvious improvement.
Phagocytotic granulomatous inflammation induced and maintained by uv-altered elastic (or elastotic) fibrous material of the skin. Relation or even identity with actinic granuloma is discussed.
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